This article explains that the hypothalamus - a small brain structure regulating appetite/aggression/sleep, is the main structure that regulates ageing in mice. The mouse brain is a typical mammal brain, and so is similar to the human brain. They found that the hypothalamus loses cells over time, and this is the cause of ageing. If stem cells are added, this can slow down the ageing process and extend life in a mouse. So it is likely this can be applied to human brains. No need to upload your brain to a computer.
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